PureCord™
Placental Tissue Banking
#1 choice of OB/GYNs,
Midwives
and
expectant parents

for newborn stem cell preservation

Placental Tissue Banking

More Stem Cells = More Options. It’s that simple.

PureCord™
Placental Tissue Banking
#1 choice of OB/GYNs,
Midwives
and
expectant parents

for newborn stem cell preservation

In order to extract the amnion and chorion layers of the placental tissue and preserve their natural multipotent cells, growth factors, and cytokines, PureCord developed the patented ExtractCryo™ processing procedure.

The amnion and chorion are cryopreserved and kept in numerous vials, guaranteeing that your child, siblings, parents, or grandparents can use them in a variety of ways. Families have the choice to employ therapeutic, wound, and ocular applications thanks to this processing technique, which also produces a tissue that is adaptable. Even more fascinating than the existing uses is the possibility. Trials using these stem cells are being conducted to develop new therapies for diseases like cancer, organ failure, heart disease, neurological dysfunction, and damage to the spine and joints.

The entire family should benefit from stem cell banking, which is why PureCord is the first and only cord blood bank to offer ExtractCryo™ Placental Processing.

While we recognise that the health of your children is your top concern, PureCord is dedicated to ensuring that the rest of your family leads healthier, longer lives using ExtractCryo™ Placental Processing. Your newborn and every other first- or second-degree relative can both be treated with these stem cells. In the event of a need, this entails that mum, dad, siblings, and even nan and grandad might utilise these cells. Giving your entire family access to the future of regenerative stem cell therapies is possible by banking this tissue.

What is Placental Tissue?

An organ with a disc shape that grows inside the uterus during pregnancy is called the placenta. It attaches to the infant through the umbilical cord. The newborn receives oxygen, nutrition, and waste-product removal from the umbilical cord.

During pregnancy, the placenta plays a crucial role. It shields the infant against viruses and bacteria by acting as a barrier. It also creates hormones and signalling molecules that aid in the development of the child.

Placental Tissue Diagram

PureCord™ collects up to twice as many stem cells as the industry standard.

PureCord™ collects up to twice as much Cord Blood as the industry standard.

View our Cord
Banking Packages

What is the importance
of Placental Tissue?

The placenta is capable of so much more than just safeguarding your unborn child! The amnion and chorion layers make up the placental membrane. The amnion layer faces the infant. The chorion layer faces the mother. Treatment options for your newborn, their siblings, parents, and even grandparents greatly increase when both layers are cryo-preserved.
Amnion
  • A thin translucent membrane containing multiple layers
  • A thickness of ~44 microns
  • Chorioncontains four to five times more growth factors/cytokines compared to Amnion
  • Amniotic Epithelial Cells,  Amniotic Mesenchymal Stem Cells
Chorion
  • A thick opaque membrane containing multiple layers
  • A thickness of ~188 microns – (roughly three to five times thicker than Amnion)
  • Chorioncontains four to five times more growth factors/cytokines compared to Amnion
  • Chorion Trophoblast Stem Cells

Foetal Membrane at term PureCord

The Placental Membrane Contains:

More in-depth examination of placental membranes by researchers has revealed that each component of the membrane is crucial to regenerative medicine. The essential components of placental membranes are:
  • Amniotic Epithelial Cells (AECs): Present on the top-most layer of amnion and can differentiate into various types of cells and tissue types.
  • Amniotic Mesenchymal Stem Cells (AMSCs): Multi-potent stem cells capable of differentiating into a number of different cells and tissue types.
  • Chorion Trophoblast Stem Cells (CTSCs): Present in the lowermost layer of chorion and are precursor cells of differentiated cells of the placenta responsible for oxygen and nutrient exchange.
  • Growth Factors: Signaling molecules that regulate cell growth and tissue regeneration.
  • Cytokines: Signaling molecules that regulate inflammation.
  • Extracellular Matrix (ECM): A three-dimensional structure consisting of various collagens and proteins that direct cellular behaviour such as differentiation, proliferation, and signalling.

The-Placenta-Membrane

Above: A scientific representation of the placental membrane’s layers. Amniotic epithelial cells and mesenchymal stem cells are the two types of stem cells found in the amnion. Bottom: A top-down view of the amnion reveals that amniotic epithelial cells are common.

Clinical Trials Using Placental Tissue

For more than a century, burns and wounds have been successfully treated with the placental membrane. The Johns Hopkins Hospital used it for the first time in 1910.

Currently being researched are amniotic mesenchymal stem cells and amniotic epithelial cells for:

  • Autoimmune diseases
  • Cancer
  • Graft vs Host disease
  • Gynaecological conditions
  • Lung diseases
  • Neurological disorders
  • Orthopaedic conditions

Several clinical trials are looking at placenta tissue that contains multipotent cells, growth factors, cytokines, and ECM. Scientists chose the amnion layer specifically because it has a structure like the skin and ocular surfaces:

Amnion Membrane
  • Corneal Healing
  • Dry Eye
Amnion + Chorion Membranes
  • Chronic Venous Leg Ulcers
  • Diabetic Foot Ulcers
  • Knee Osteoarthritis
  • Pressure Ulcers

Placental Tissue Vs. Cord Blood

Few private cord blood banks offer placental tissue banking, however several do cryopreserve cord tissue. The only firm that provides ExtractCryo™ processing for cord tissue and placental tissue is PureCord. Compared to cord tissue, placental tissue has a wider variety of cell types.
Cord blood can treat:
Cord Derived Mesenchymal Stem Cells (C-MSCs)
Growth Factors
Cytokines
Extracellular Matrix Protiens (ECM)
Placental tissue:
Amnion Derived Mesenchymal Stem Cells (A-MSCs)
Amniotic Epithelial Cells (AECs)
Growth Factors
Cytokines
Extracellular Matrix Proteins (ECM)
Tropoblasts
Application usage for cord tissue and placental tissue is distinct. Inside the body, cord tissue is applied during surgery (ex: tendon repair, cartilage repair, or orthopaedic surgery). tissue from the placenta utilised for external applications (ex: wound healing, treating eye conditions, ulcers).

PureCord ExtractCryo™
Placental Tissue Processing

In order to extract the amnion and chorion layers of the placental tissue and preserve their natural multipotent cells, growth factors, and cytokines, PureCord developed the patented ExtractCryo™ processing procedure.
The amnion and chorion are cryopreserved and kept in numerous vials, guaranteeing that your child, siblings, parents, or grandparents can use them in a variety of ways. Families have the choice to employ this adaptable tissue thanks to this processing technology because:
  • Chorion trophoblast stem cells, amniotic mesenchymal stem cells, and amniotic epithelial cells for therapeutic purposes.
  • Multipotent cells, growth factors, and cytokines are present in amniotic tissue (amnion + chorion), which is used in wound and eye applications.

Everything you need to know
about placental tissue banking

After delivery, the placenta is harvested for its stem cells, which are then saved for potential medicinal or therapeutic use.
The placenta is a valuable source of two types of stem cells, mesenchymal stem cells (MSCs) and amniotic epithelial cells (AECs), that are at the core of cutting-edge clinical trials to create new treatments for a variety of ailments, including cerebral palsy, cancer, organ failure, and damage to the bones and joints, in addition to being used to heal wounds and some eye disorders.
PureCord provides collection kits for people who want to store placental tissue. The placenta is placed in the kit after delivery and picked up by a medical courier who then transports it to our laboratory for processing and storage.
It is now possible to safely treat all first- and second-degree relatives with stem cells taken from placental tissue, which is a ground-breaking advancement in stem cell therapy. This fact, along with the extraordinarily wide range of treatment options available at the clinical trial stage, makes placental tissue banking an essential factor for any family to take into account.
To treat wounds, including surgical scars, and various eye diseases, including some that can result in blindness, placental tissue is currently licenced for use. Even more potential for treatment is being investigated as trials are being conducted on a variety of malignancies, organ diseases, and injuries to the bones and joints.
Placental tissue can be effectively and safely kept indefinitely under the right circumstances, just as cord blood. The most popular storage plans at PureCord are for 20 years. There are lifetime storage options available as well as the ability to extend these plans at any time.
2011 saw a rise in the popularity of private placental tissue banking, the same year Pure Medical’s sister company Stem Cell Health started providing the service. In 2021, PureCord unveiled Placental Tissue ExtractCryo™, the most sophisticated method that allows stem cells to be used in the widest range of applications.
With flexible payment choices like one-time, annual, and monthly payment plans, PureCord aims to make stem cell banking as inexpensive as possible for more families. Costs for the first year might be as low as £699.
All first- and second-degree relatives can safely use the stem cells found in placental tissue. Therefore, banking gives siblings, parents, and even grandparents access to stem cell-based therapies and studies.

References:

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